A mental well-being condition marked by a continuous low-spirited state or diminished enthusiasm for daily pursuits, leading to a substantial disruption in one’s everyday existence. Depression varies in intensity from moderate, short-term instances of unhappiness to intense, long-lasting despondency. Severe depression, otherwise known as major depressive disorder or simply major depression, is the more extreme manifestation of this condition. It is distinct from depression that arises due to specific events, such as bereavement, or medical issues like thyroid dysfunction.

In order to identify severe depression, numerous physicians employ the diagnostic guidelines for major depressive disorder found in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is issued by the American Psychiatric Association.

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Common Causes Of Depression

Numerous factors can contribute to an increased likelihood of depression, including:

  • Abuse: Experiencing physical, sexual, or emotional abuse can heighten one’s susceptibility to depression in later stages of life.
  • Aging: Elderly individuals face a greater risk of depression, which can be exacerbated by additional factors such as social isolation and limited support networks.
  • Specific medications: Certain medications, including isotretinoin (for acne treatment), the antiviral drug interferon-alpha, and corticosteroids, have been associated with an elevated risk of developing depression.
  • Interpersonal conflicts: Individuals with a biological predisposition to depression may experience depressive symptoms in response to personal conflicts or disputes with friends or family members.
  • Bereavement or loss: While experiencing sadness or grief after losing a loved one is natural, these emotions can escalate the risk of depression.
  • Gender: Women are approximately twice as likely as men to suffer from depression, potentially due to hormonal fluctuations throughout their lives.
  • Genetic factors: A family history of depression may heighten the risk. Depression is considered a complex trait, suggesting that multiple genes with small effects may contribute to the condition, as opposed to a single gene responsible for purely genetic diseases like Huntington’s disease or cystic fibrosis.
  • Major life events: Both positive and negative life events, such as starting a new job, graduating, getting married, relocating, losing a job or income, going through a divorce, or retiring, can trigger depression. However, clinical depression surpasses a “normal” reaction to stressful life occurrences.
  • Additional personal issues: Social isolation stemming from other mental health disorders or exclusion from a family or social group can increase the risk of developing clinical depression.
  • Co-existing medical conditions: In some cases, depression can co-occur with a major illness or be triggered by another medical condition, necessitating a comprehensive approach to treatment and care.

Symptoms Of Depression

  • Experiencing persistent emotions such as sadness, hopelessness, or a sense of emptiness
  • Frequent episodes of irritability, anger, or frustration, even in response to minor incidents
  • Diminished interest or enjoyment in activities that were once pleasurable, including hobbies, sports, or intimacy
  • Sleep disturbances, which could involve either insomnia or excessive sleep
  • Fatigue and decreased energy levels, making routine tasks feel more challenging
  • Changes in appetite and weight, such as reduced hunger and weight loss or increased cravings leading to weight gain
  • Persistent anxiety, agitation, or a feeling of restlessness
  • Slower cognitive and physical processes, including speech, thought, and movement
  • A sense of worthlessness or excessive guilt, often focusing on past failures or blaming oneself
  • Difficulties with memory, concentration, decision-making, and problem-solving
  • Recurring thoughts of death, suicidal ideation, suicide attempts, or actual suicide
  • Physical symptoms without a clear cause, like persistent headaches or back pain

It is essential to recognize these signs and symptoms to seek appropriate professional help and support for individuals who may be experiencing clinical depression.

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